Shared Genetic Relationships Underlying Generalized Vitiligo and Autoimmune Thyroid Disease
نویسندگان
چکیده
منابع مشابه
Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.
BACKGROUND Generalized vitiligo is an autoimmune disease of skin pigmentation that is associated with increased prevalence of other autoimmune diseases, particularly autoimmune thyroid disease (AITD; principally Hashimoto's disease and Graves' disease), both in vitiligo patients and their close relatives, suggesting a heritable predisposition involving, in part, shared susceptibility genes. S...
متن کاملVitiligo and Autoimmune Thyroid Disorders
Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected by vitiligo usually show a poorer quality of life and are more likely to suff...
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The occurrence of three or more autoimmune disorders in one patient defines multiple autoimmune syndrome. The pathogenesis of multiple autoimmune syndrome is not known yet and environmental triggers and genetic susceptibility have been suggested to be involved. Herein, we report a 47-year-old woman who had Hashimoto's thyroiditis, vitiligo and newly diagnosed ulcerative colitis. Diagnosis of ul...
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The autoimmune thyroid diseases (AITDs) (Graves' disease and Hashimoto's thyroiditis) are complex genetic diseases which most likely have more than 20 genes contributing to the clinical phenotypes. To date, the genes known to be contributing fall into two categories: immune regulatory genes (including HLA, CTLA4, PTPN22, CD40, CD25, and FCRL3) and thyroid-specific genes (TG and TSHR). However, ...
متن کاملautoimmune thyroid disorders in patients with vitiligo
objectives we aimed to assess the prevalence of autoimmune thyroid disorders among patients with vitiligo who referred to sina hospital of hamadan in west of iran in 2008. patients and methods this case-control study comprised 45 patients with vitiligo and 45 healthy individuals (control group). data on age, gender, family history of vitiligo, distribution pattern and duration of the disease we...
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ژورنال
عنوان ژورنال: Thyroid
سال: 2010
ISSN: 1050-7256,1557-9077
DOI: 10.1089/thy.2010.1643